Like I said, it's really impossible to gauge a finite level of improvment for a given level of adjustment of an actuator.
I would suggest to never adjust an actuator any more than 2 full 360 degree turns at a time.
It's POSSIBLE, but NOT guaranteed, that 2 full turns MAY net somewhere in the neighborhood of a 100 RPM sooner spool up of the turbo or 100 RPM later onset of the taper of boost towards redline, but again, there are no guarantees.
Like I said, overall peak boost may not be affected too greatly when still using the OEM N75 valve to control boost. On another application using a manual boost controller or running off of wastegate pressure alone, where the ECU doesn't have full control over boost, adjustments can, indeed, net gains to the peak boost output of the turbo.
It is possible to tighten a wastegate actuator too much as well.
It is doubtful that the OEM actuator spring pressure and the units adjustment range is such that you could ever add enough pre-load to prevent the unit from opening altogther, which would result in a severe overboost condition, but tightening the unit too far may affect the boost curve in such a way that the onset of boost pressure or the overall shape of the curve is different from that which the ECU is looking for.
If spool is reached too quickly or boost doesn't taper enough towards redline, as the ECU is using the MAP sensor to measure boost pressure continuously and it is looking for a specific level at specific points, the ECU may find a "fault" with the new curve and may throw a soft fault code or even a check engine light.
Consider that power potential will be dependent upon fuel delivery as well, so you can't expect power to increase solely by changing the boost curve if the ECU isn't capable of making the corresponding adjustments to the fuel trims as well.
Like I said, you're not going to blow up your turbo, but you need to make adjustments cautiously and in small increments being very careful to note changes along the way. If you reach a point at which the ECU begins to intervene (soft fault code, check engine light, fuel cut, limp mode, etc.) you've gone too far beyond what perameters the ECU (in it's current state of tune) will allow.